Osteoporosis is a bone disease involving loss of bone tissue. According to the National Osteoporosis Foundation, approximately nine million adults in the U.S. have osteoporosis, consisting mostly of older, postmenopausal women, and additionally 48 million exhibit low bone mass. To study the benefits of a diet rich in antioxidants on bone loss prevention, we conducted a two-month study on surgically ovariectomized (OVX) rats given orange pulp at 10% and 25%, which are abundant source of antioxidants. At the study’s conclusion, rats were sacrificed to obtain measurements on bone strength, and bone density. Although antioxidant status was suppressed in the OVX group, feeding orange pulp increased, but did not reach the level of the sham group. Bone loss was observed (P<0.05) in OVX rats versus control (sham) group, however, OVX rats eating orange pulp had significantly (P<0.05) greater femoral and 5th lumbar bone density and strength, compared to OVX rats receiving no pulp. The increase (P<0.05) in bone strength and bone density of orange pulp groups reached the level of the sham group. This study suggests that eating orange pulp benefit individuals with osteoporosis and the mode of action may be mediated by the antioxidant status. Key words: osteoporosis, antioxidant diet, therapy, ovariectomy, orange pulp
August 28, 2015
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